Senior Director, Global Health Economics & Outcomes Research

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Role Summary:

The Senior Director, Global Health Economics & Outcomes Research (GHEOR) will advance the strategic objectives of GHEOR, Global Medical Affairs (GMA), and the broader organization by driving patient access through optimal pricing and reimbursement for Madrigal Pharmaceuticals’ medicines, with a primary focus on Rezdiffra.

This position primarily drives evidence generation and market access initiatives while collaborating with US, European and other international GHEOR counterparts to ensure alignment of global strategies. The Senior Director will oversee the development and execution of integrated evidence plans, including design, analysis, and dissemination of HEOR studies and technical deliverables. Responsibilities include based health technology assessment (HTA) engagement, real-world evidence generation, economic modeling, and collaboration with teams to inform international HTA submissions and payer strategies. This role directly impacts the achievement of global business objectives by providing strategic leadership and delivering robust evidence generation to demonstrate the value of Madrigal’s therapies in liver health.

The Senior Director, GHEOR, will be responsible for designing and executing HEOR strategies and projects aligned with the global integrated evidence plan. This includes oversight of evidence generation activities, management of RWD studies, and dissemination of scientific and technical deliverables. Reporting to the Vice President, GHEOR, the incumbent will partner closely with Global Medical Affairs, Clinical Development & Biostatistics, Access and Commercial, and Regional and In-Country teams to foster innovation, advance population health outcomes, and promote patient centricity.

This position is hybrid, based in Conshohocken, PA, with an expected on-site presence three days per week. All incumbents are expected to adhere to applicable Madrigal and divisional policies and procedures.

Key Responsibilities and Primary Activities: 

• Analytical Expertise and Technical Skills
  • Demonstrate strong analytical background in biostatistics, public health, or epidemiology with hands-on experience in real-world data (RWD) analysis
  • Possess in-depth expertise in R and SAS programming, with familiarity in commonly used RWD sources such as administrative claims and electronic health records (EHR) databases
  • Economic modeling, QoL, HTA technologies
• Real-World Evidence (RWE) and HEOR Research
  • Support real-world research projects in RWE and HEOR to generate actionable insights that inform business and clinical strategy
  • Conduct both rapid analyses and full protocol-driven observational studies, ensuring robust and scientifically sound methodologies
  • Proactively test hypotheses using data-driven approaches to inform company strategies and decision-making
• • Cross-Functional Collaboration and Communication
  • Collaborate effectively with cross-functional stakeholders to define research questions, shape analyses, and communicate findings in a clear and impactful manner
  • Present study results at scientific conferences and publish research in peer-reviewed journals to enhance scientific visibility and credibility
• Continuous Learning and Industry Awareness
  • Stay current with emerging trends, best practices, and advancements in RWE and HEOR methodologies
  • Contribute to continuous improvement of analytical tools, research processes, and data standards across the organization
• Budget Oversight and Resource Management
  • Support the GHEOR budget planning forecasting and allocation to ensure efficient use of resources across global and regional initiatives
  • Manage external vendor contracts and timelines to ensure project deliverables are completed on time within scope and within budget
• Team Leadership & Development
  • Foster continuous development through mentoring and training
• Compliance & Quality
  • Ensure all activities comply with company SOPs, industry standards, and applicable regulations
  • Uphold the highest ethical standards in all external engagements
• Travel Requirement
  • Willingness to travel both locally and internationally up to 30% for conferences, various corporate locations, and stakeholder meetings, including overnight trips
  • Ability to work across global time zones

Required Qualifications, Skills & Experience:

• MS/PhD in biostatistics, public health, epidemiology, or a similar field
• 12+ years' experience in HEOR methods with a proven track record of delivering results (PhD substitutes for 7 years)
• Experience in delivering ad-hoc and full protocol-driven HEOR and observational studies
• Ability to program and/or validate code across multiple languages (e.g., SAS and R)
• A strong track record of publications
• Strong communications skill and interpersonal skills with ability to engage multiple internal and external stakeholders
• Exceptional written and verbal English communication skills
• Demonstrated ability to assess and prioritize projects based on business value
• Execution-focused mindset with emphasis on efficiency and results
• Strong project management skills in contracting, budgeting, and vendor oversight; adept at multitasking under shifting priorities
• Effective influencer within cross-functional and matrixed environments
• Highly organized and detail-oriented with proactive problem-solving abilities
• Adaptable and comfortable managing change and tight timelines
• High proficiency with project management systems, Medical Affairs dashboards, CRM platforms, and enterprise collaboration tools (e.g., Veeva, Microsoft Office Suite, SharePoint, Teams, Zoom)

Preferred Attributes:

• In-depth knowledge of liver disease in the RWD space; experience in cardiometabolic health or Metabolic Dysfunction-Associated Steatohepatitis
• PhD preferred
• Extensive experience building, embedding and leading RWD capabilities in leading pharmaceutical enterprises
• Recruitment, deployment, management and development of RWE staff capabilities
• Extensive publication record and status as a leader in industry RWD/E development and delivery

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $272,000 - $332,000 per year

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com.