Director, Global Health Economics & Outcomes Research

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Role Summary:

The Director, Global Health Economics & Outcomes Research (GHEOR) will lead the GHEOR strategy supporting Global Medical Affairs (GMA) and business objectives to optimize patient access, pricing, and reimbursement for Madrigal Pharmaceutical’s medicines, with a focus on Rezdiffra in the US and international markets.

This position primarily drives evidence generation and market access initiatives while collaborating with US, European and other international GHEOR counterparts to ensure alignment of global strategies. The Director will oversee the development and execution of integrated evidence plans, including design, analysis, and dissemination of HEOR studies and technical deliverables. Responsibilities include based health technology assessment (HTA) engagement, real-world evidence generation, economic modeling, and collaboration with teams to inform international HTA submissions and payer strategies.

The Director will work closely with GMA, Clinical Development & Biostatistics, Access & Commercial, and regional teams to foster a patient-centric, evidence-driven culture, and will report to the Executive Director, GHEOR in a hybrid role based in Conshohocken, PA (expected 3 days in-office).

All incumbents are responsible for adhering to applicable Madrigal policies and procedures.

Key Responsibilities and Primary Activities: 

Approximately 50% of this role is dedicated to executing one or more functional priorities and objectives, while the remaining 50% focuses on providing strategic direction, adapting priorities to achieve organizational goals, and leading the team.

• Strategy Development
  • Lead the evidence generation strategy for Rezdiffra with HQ-based stakeholders in partnership with the cross-functional matrix team
  • Integrate input from US and international teams into a comprehensive evidence strategy to support market access, reimbursement, and lifecycle management
• Evidence Generation and HEOR Studies
  • Design and execute HEOR studies including network meta-analyses and real-world studies, from concept through publication
  • Develop launch and HTA deliverables such as value dossiers, systematic literature reviews, economic models, and innovative tools to support payer engagement, reimbursement, and access
• Clinical and Regulatory Support
  • Provide strategic input into clinical trial design to support payer and regulatory decisions
  • Partner with internal stakeholders to ensure appropriate dissemination of HEOR materials per regulatory guidance and internal SOPs
• External Collaboration and Partnerships
  • Develop strategic partnerships and research collaborations with key external experts healthcare policymakers payers and academic and community oncology settings to support asset strategies
• Budget Oversight and Resource Management
  • Support the GHEOR budget planning forecasting and allocation to ensure efficient use of resources across US and international initiatives
  • Manage external vendor contracts and timelines to ensure project deliverables are completed on time within scope and within budget
• Team Leadership & Development
  • Foster continuous development through mentoring and training
  • Align Publications activities with strategic objectives and tactical plans
• Compliance & Quality
  • Ensure all activities comply with company SOPs, industry standards, and applicable regulations
  • Uphold the highest ethical standards in all external engagements
• Travel Requirement
  • Willingness to travel up to 30%, primarily in the US, with occasional international travel for conferences or collaboration with all GHEOR teams
  • Ability to work across international time zones as needed

Required Qualifications, Skills & Experience:

• Graduate degree in health economics, epidemiology, health services research, or a related field
• 12-15+ years of HEOR or related experience with 7+ years with PhD
• Direct experience with US health technology assessment (HTA) and value assessment bodies (e.g., ICER) and familiarity with select international HTA agencies (e.g., NICE, CADTH)
• Deep expertise in health services research methods, including economic modeling, patient-reported outcomes (PROs), statistics, and real-world evidence studies
• Proven ability to independently design, execute, and manage complex non-interventional studies in the US and internationally
• Strong understanding of the US drug development process and payer landscape
• Excellent interpersonal and influencing skills to engage multiple internal and external stakeholders across cross-functional and matrixed teams
• Execution-focused and highly organized, with strong project management skills in budgeting, contracting, vendor oversight, and the ability to manage multiple priorities under tight timelines
• Exceptional written and verbal communication skills in English, with experience preparing technical and value-based materials for diverse audiences
• Demonstrated ability to assess and prioritize projects based on business value, with a proactive approach to problem-solving and adapting to change
• High proficiency with project management systems, Medical Affairs dashboards, CRM platforms, and enterprise collaboration tools (e.g., Veeva, Microsoft Office Suite, SharePoint, Teams, Zoom)

Preferred Attributes:

• In-depth knowledge of liver disease; experience in cardiometabolic health or Metabolic Dysfunction-Associated Steatohepatitis
• PhD degree in health economics, epidemiology, health services research, or a related field
• International mobility
• Experience supporting international launch

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $224,000 - $274,000 per year

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR@madrigalpharma.com.